Drug interactions
Duvelisib + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Duvelisib and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits P-gp and BCRP, which may increase duvelisib exposure. Because duvelisib has serious toxicities such as infections, diarrhea, colitis and skin reactions, higher levels could increase risk.
What this interaction means in plain words
Duvelisib and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Velpatasvir inhibits intestinal P-gp and BCRP efflux of duvelisib, increasing its absorption.
What to do
Monitor for duvelisib adverse effects such as diarrhea, rash and infection. Reduce the duvelisib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Duvelisib and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits P-gp and BCRP, which may increase duvelisib exposure. Because duvelisib has serious toxicities such as infections, diarrhea, colitis and skin reactions, higher levels could increase risk.
How serious is the interaction between Duvelisib and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for duvelisib adverse effects such as diarrhea, rash and infection. Reduce the duvelisib dose if toxicity develops.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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