Drug interactions
Duvelisib + Solifenacin
Severity: Moderate
Duvelisib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise solifenacin exposure. This increases the risk of anticholinergic adverse effects and possibly QT prolongation.
What this interaction means in plain words
Duvelisib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duvelisib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Duvelisib inhibits CYP3A4, reducing the first-pass and systemic metabolism of solifenacin.
What to do
Monitor for anticholinergic toxicity such as urinary retention, constipation and blurred vision. Consider a lower solifenacin dose, and do not exceed 5 mg daily where CYP3A4 inhibition is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Solifenacin?
MediHelp rates the interaction as moderate. Duvelisib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and can raise solifenacin exposure. This increases the risk of anticholinergic adverse effects and possibly QT prolongation.
How serious is the interaction between Duvelisib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, constipation and blurred vision. Consider a lower solifenacin dose, and do not exceed 5 mg daily where CYP3A4 inhibition is significant.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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