Drug interactions
Edoxaban + Fluoxetine
Severity: Moderate
Edoxaban and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine impairs platelet aggregation through serotonin depletion, adding to the anticoagulant effect of edoxaban. Bleeding risk, particularly gastrointestinal, is increased.
What this interaction means in plain words
Edoxaban and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: SSRI-related platelet dysfunction plus factor Xa inhibition.
What to do
Monitor for signs of bleeding and hemoglobin changes. Consider gastroprotection when other risk factors such as NSAIDs or age are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Edoxaban with Fluoxetine?
MediHelp rates the interaction as moderate. Edoxaban and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine impairs platelet aggregation through serotonin depletion, adding to the anticoagulant effect of edoxaban. Bleeding risk, particularly gastrointestinal, is increased.
How serious is the interaction between Edoxaban and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin changes. Consider gastroprotection when other risk factors such as NSAIDs or age are present.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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