Drug interactions
Edoxaban + Indomethacin
Severity: Major
Edoxaban and Indomethacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin inhibits platelet function and can cause gastrointestinal mucosal injury, so adding it to edoxaban increases the risk of clinically significant bleeding. Chronic NSAID use further raises this risk.
What this interaction means in plain words
Edoxaban and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect on hemostasis: factor Xa inhibition plus NSAID antiplatelet activity and mucosal damage.
What to do
Avoid regular NSAID use with edoxaban; if short-term use is unavoidable, monitor for bleeding signs and hemoglobin and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Indomethacin?
MediHelp rates the interaction as major. Edoxaban and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin inhibits platelet function and can cause gastrointestinal mucosal injury, so adding it to edoxaban increases the risk of clinically significant bleeding. Chronic NSAID use further raises this risk.
How serious is the interaction between Edoxaban and Indomethacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with edoxaban; if short-term use is unavoidable, monitor for bleeding signs and hemoglobin and consider gastroprotection.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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