Drug interactions
Edoxaban + Ketoprofen
Severity: Major
Edoxaban and Ketoprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking ketoprofen with edoxaban increases the risk of clinically significant bleeding, including gastrointestinal hemorrhage. Chronic NSAID use makes this more likely.
What this interaction means in plain words
Edoxaban and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
Additive hemostatic impairment: factor Xa inhibition plus NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid regular NSAID use and prefer paracetamol; if combined, use the shortest duration and monitor for signs of bleeding and anemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Ketoprofen?
MediHelp rates the interaction as major. Edoxaban and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking ketoprofen with edoxaban increases the risk of clinically significant bleeding, including gastrointestinal hemorrhage. Chronic NSAID use makes this more likely.
How serious is the interaction between Edoxaban and Ketoprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use and prefer paracetamol; if combined, use the shortest duration and monitor for signs of bleeding and anemia.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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