Drug interactions
Edoxaban + Levetiracetam
Severity: Moderate
Edoxaban and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam has been suggested to lower exposure to some direct oral anticoagulants, possibly through P-glycoprotein induction. Reduced edoxaban exposure could lessen protection against thromboembolism, but the evidence is limited.
What this interaction means in plain words
Edoxaban and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Levetiracetam belongs to Central Nervous System.
Why it happens
Possible induction of intestinal P-glycoprotein reducing edoxaban absorption; mechanism not firmly established.
What to do
Be alert for thromboembolic events when starting or increasing levetiracetam. Consider an alternative anticonvulsant if the anticoagulant effect is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Edoxaban with Levetiracetam?
MediHelp rates the interaction as moderate. Edoxaban and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levetiracetam has been suggested to lower exposure to some direct oral anticoagulants, possibly through P-glycoprotein induction. Reduced edoxaban exposure could lessen protection against thromboembolism, but the evidence is limited.
How serious is the interaction between Edoxaban and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be alert for thromboembolic events when starting or increasing levetiracetam. Consider an alternative anticonvulsant if the anticoagulant effect is a concern.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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