Drug interactions
Edoxaban + Nicardipine
Severity: Moderate
Edoxaban and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits P-glycoprotein and may increase edoxaban exposure. The effect is expected to be modest but could raise bleeding risk.
What this interaction means in plain words
Edoxaban and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of intestinal and renal P-glycoprotein efflux increases edoxaban absorption and reduces its clearance.
What to do
No routine edoxaban dose change is generally needed; monitor for bleeding, especially with renal impairment or low body weight. Review the dose if other bleeding-risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Nicardipine?
MediHelp rates the interaction as moderate. Edoxaban and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits P-glycoprotein and may increase edoxaban exposure. The effect is expected to be modest but could raise bleeding risk.
How serious is the interaction between Edoxaban and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine edoxaban dose change is generally needed; monitor for bleeding, especially with renal impairment or low body weight. Review the dose if other bleeding-risk factors are present.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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