Drug interactions
Edoxaban + Propafenone
Severity: Moderate
Edoxaban and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits P-glycoprotein, which can modestly raise edoxaban concentrations and anticoagulant effect. The clinical effect is generally limited and the two drugs are often used together in atrial fibrillation, though bleeding risk may increase.
What this interaction means in plain words
Edoxaban and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Propafenone belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by propafenone reduces edoxaban efflux and increases exposure.
What to do
Continue the standard edoxaban dose for atrial fibrillation and monitor for bleeding, particularly with renal impairment or low body weight. Review dose according to labeling when treating venous thromboembolism.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Edoxaban and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Propafenone?
MediHelp rates the interaction as moderate. Edoxaban and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits P-glycoprotein, which can modestly raise edoxaban concentrations and anticoagulant effect. The clinical effect is generally limited and the two drugs are often used together in atrial fibrillation, though bleeding risk may increase.
How serious is the interaction between Edoxaban and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue the standard edoxaban dose for atrial fibrillation and monitor for bleeding, particularly with renal impairment or low body weight. Review dose according to labeling when treating venous thromboembolism.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
