Drug interactions
Edoxaban + Quinidine
Severity: Moderate
Edoxaban and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine raises edoxaban exposure by inhibiting P-glycoprotein, which may increase bleeding risk. The increase is moderate and is considered clinically manageable in most settings.
What this interaction means in plain words
Edoxaban and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits P-glycoprotein efflux of edoxaban, increasing absorption and reducing elimination.
What to do
For DVT/PE treatment, use edoxaban 30 mg once daily as labeled with strong P-gp inhibitors. For atrial fibrillation, no routine reduction is needed, but monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Quinidine?
MediHelp rates the interaction as moderate. Edoxaban and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine raises edoxaban exposure by inhibiting P-glycoprotein, which may increase bleeding risk. The increase is moderate and is considered clinically manageable in most settings.
How serious is the interaction between Edoxaban and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For DVT/PE treatment, use edoxaban 30 mg once daily as labeled with strong P-gp inhibitors. For atrial fibrillation, no routine reduction is needed, but monitor for bleeding.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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