Drug interactions
Edoxaban + Ritonavir
Severity: Major
Edoxaban and Ritonavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits P-glycoprotein and CYP3A4 and can raise edoxaban concentrations, increasing the risk of bleeding. The effect depends on the indication and renal function.
What this interaction means in plain words
Edoxaban and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of P-gp-mediated intestinal efflux and renal secretion increases edoxaban exposure.
What to do
Avoid if possible or use an alternative anticoagulant. If combined, monitor for bleeding and renal function and follow edoxaban labeling for dose adjustment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Edoxaban with Ritonavir?
MediHelp rates the interaction as major. Edoxaban and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir inhibits P-glycoprotein and CYP3A4 and can raise edoxaban concentrations, increasing the risk of bleeding. The effect depends on the indication and renal function.
How serious is the interaction between Edoxaban and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or use an alternative anticoagulant. If combined, monitor for bleeding and renal function and follow edoxaban labeling for dose adjustment.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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