Drug interactions
Edoxaban + Sarecycline
Severity: Minor
Edoxaban and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline has shown P-gp inhibition in vitro, which could slightly raise edoxaban absorption. Systemic exposure is modest, so the clinical impact is likely small.
What this interaction means in plain words
Edoxaban and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Edoxaban belongs to Cardiovascular; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible weak inhibition of P-glycoprotein efflux of edoxaban.
What to do
No dose adjustment is routinely needed; monitor for bleeding during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Edoxaban with Sarecycline?
MediHelp rates the interaction as minor. Edoxaban and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline has shown P-gp inhibition in vitro, which could slightly raise edoxaban absorption. Systemic exposure is modest, so the clinical impact is likely small.
How serious is the interaction between Edoxaban and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed; monitor for bleeding during co-therapy.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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