Drug interactions
Edoxaban + Sertraline
Severity: Moderate
Edoxaban and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline reduces platelet serotonin and aggregation, which adds to the anticoagulant effect of edoxaban. Bleeding risk is increased, particularly in the GI tract.
What this interaction means in plain words
Edoxaban and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: SSRI-related platelet dysfunction plus factor Xa inhibition.
What to do
Monitor for signs of bleeding and anemia. Consider gastroprotection in patients at higher risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Edoxaban with Sertraline?
MediHelp rates the interaction as moderate. Edoxaban and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline reduces platelet serotonin and aggregation, which adds to the anticoagulant effect of edoxaban. Bleeding risk is increased, particularly in the GI tract.
How serious is the interaction between Edoxaban and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and anemia. Consider gastroprotection in patients at higher risk.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
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