Drug interactions
Edoxaban + Sulindac
Severity: Major
Edoxaban and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs raise the risk of bleeding, and sulindac may also cause gastrointestinal ulceration. Using them together increases the likelihood of serious hemorrhage compared with edoxaban alone.
What this interaction means in plain words
Edoxaban and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Sulindac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect: factor Xa inhibition plus NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid regular NSAID use in patients taking edoxaban and prefer paracetamol. If unavoidable, give the shortest course and monitor for signs of bleeding and falls in hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Sulindac?
MediHelp rates the interaction as major. Edoxaban and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs raise the risk of bleeding, and sulindac may also cause gastrointestinal ulceration. Using them together increases the likelihood of serious hemorrhage compared with edoxaban alone.
How serious is the interaction between Edoxaban and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use in patients taking edoxaban and prefer paracetamol. If unavoidable, give the shortest course and monitor for signs of bleeding and falls in hemoglobin.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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