Drug interactions
Edoxaban + Ticagrelor
Severity: Major
Edoxaban and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor provides potent platelet inhibition, and with edoxaban the risk of major and minor bleeding is increased. Ticagrelor is generally not preferred as the P2Y12 inhibitor alongside an oral anticoagulant because of this higher bleeding risk.
What this interaction means in plain words
Edoxaban and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Edoxaban belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of reversible P2Y12 receptor antagonism and factor Xa inhibition.
What to do
Prefer clopidogrel as the P2Y12 inhibitor if combined antithrombotic therapy is required. If ticagrelor is used, keep the duration short and monitor for bleeding and haemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Edoxaban and Ticagrelor, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Edoxaban with Ticagrelor?
MediHelp rates the interaction as major. Edoxaban and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticagrelor provides potent platelet inhibition, and with edoxaban the risk of major and minor bleeding is increased. Ticagrelor is generally not preferred as the P2Y12 inhibitor alongside an oral anticoagulant because of this higher bleeding risk.
How serious is the interaction between Edoxaban and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer clopidogrel as the P2Y12 inhibitor if combined antithrombotic therapy is required. If ticagrelor is used, keep the duration short and monitor for bleeding and haemoglobin.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Defibrotide, Ketorolac. The full list is on the Edoxaban page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
