Drug interactions
Edoxaban + Verapamil
Severity: Moderate
Edoxaban and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and can raise edoxaban plasma concentrations modestly. Higher exposure may increase the risk of bleeding, although the effect is smaller than with the strongest P-gp inhibitors.
What this interaction means in plain words
Edoxaban and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Edoxaban belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of edoxaban in the gut and kidney increases its absorption and reduces its clearance.
What to do
In atrial fibrillation no edoxaban dose change is generally needed, but monitor for bleeding and renal function. For VTE treatment, follow the product labeling for P-gp inhibitor dosing and reassess bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Edoxaban
- Apixaban + Edoxaban Contraindicated
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
Frequently asked questions
Can I take Edoxaban with Verapamil?
MediHelp rates the interaction as moderate. Edoxaban and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein and can raise edoxaban plasma concentrations modestly. Higher exposure may increase the risk of bleeding, although the effect is smaller than with the strongest P-gp inhibitors.
How serious is the interaction between Edoxaban and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In atrial fibrillation no edoxaban dose change is generally needed, but monitor for bleeding and renal function. For VTE treatment, follow the product labeling for P-gp inhibitor dosing and reassess bleeding risk.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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