Drug interactions
Efavirenz + Eletriptan
Severity: Moderate
Efavirenz and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is metabolized by CYP3A4, and efavirenz induces this enzyme, which can reduce eletriptan exposure and migraine relief. The effect is of limited severity, and efavirenz is a weaker inducer than rifampin.
What this interaction means in plain words
Efavirenz and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Eletriptan belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of eletriptan.
What to do
Monitor for reduced headache response, and if the response is inadequate consider a triptan not dependent on CYP3A4, such as sumatriptan or rizatriptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Efavirenz with Eletriptan?
MediHelp rates the interaction as moderate. Efavirenz and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is metabolized by CYP3A4, and efavirenz induces this enzyme, which can reduce eletriptan exposure and migraine relief. The effect is of limited severity, and efavirenz is a weaker inducer than rifampin.
How serious is the interaction between Efavirenz and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced headache response, and if the response is inadequate consider a triptan not dependent on CYP3A4, such as sumatriptan or rizatriptan.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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