Drug interactions
Efavirenz + Goserelin
Severity: Moderate
Efavirenz and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy such as goserelin can prolong the QT interval, and efavirenz has similar potential. The combination may add to arrhythmia risk, particularly in patients with other risk factors.
What this interaction means in plain words
Efavirenz and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and electrolytes and repeat periodically. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Efavirenz with Goserelin?
MediHelp rates the interaction as moderate. Efavirenz and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy such as goserelin can prolong the QT interval, and efavirenz has similar potential. The combination may add to arrhythmia risk, particularly in patients with other risk factors.
How serious is the interaction between Efavirenz and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat periodically. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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