Drug interactions
Efavirenz + Indacaterol
Severity: Moderate
Efavirenz and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval in a concentration-related manner, and indacaterol may add to arrhythmic risk. The effect is most relevant in patients with electrolyte disturbances or other QT-prolonging medication.
What this interaction means in plain words
Efavirenz and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Indacaterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Consider an ECG in patients with other risk factors for QT prolongation. Correct electrolyte abnormalities and monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Indacaterol?
MediHelp rates the interaction as moderate. Efavirenz and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can prolong the QT interval in a concentration-related manner, and indacaterol may add to arrhythmic risk. The effect is most relevant in patients with electrolyte disturbances or other QT-prolonging medication.
How serious is the interaction between Efavirenz and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG in patients with other risk factors for QT prolongation. Correct electrolyte abnormalities and monitor for palpitations or syncope.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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