Drug interactions
Efavirenz + Ixazomib
Severity: Moderate
Efavirenz and Ixazomib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ixazomib is partly cleared by CYP3A4, and strong inducers markedly reduce its exposure. Efavirenz is a weaker inducer, but a meaningful reduction in ixazomib efficacy is possible.
What this interaction means in plain words
Efavirenz and Ixazomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Ixazomib belongs to Oncology.
Why it happens
CYP3A4 induction by efavirenz increases ixazomib metabolism.
What to do
Prefer an antiretroviral without CYP3A induction. If it is combined, monitor myeloma response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Efavirenz with Ixazomib?
MediHelp rates the interaction as moderate. Efavirenz and Ixazomib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ixazomib is partly cleared by CYP3A4, and strong inducers markedly reduce its exposure. Efavirenz is a weaker inducer, but a meaningful reduction in ixazomib efficacy is possible.
How serious is the interaction between Efavirenz and Ixazomib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiretroviral without CYP3A induction. If it is combined, monitor myeloma response closely.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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