Drug interactions
Efavirenz + Levamlodipine
Severity: Moderate
Efavirenz and Levamlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower levamlodipine concentrations, diminishing antihypertensive effect. Quantitative data are limited, but the interaction is plausible given CYP3A4 involvement.
What this interaction means in plain words
Efavirenz and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Levamlodipine belongs to Cardiovascular.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of levamlodipine.
What to do
Monitor blood pressure and increase the levamlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Levamlodipine
- Dantrolene + Levamlodipine Major
- Amiodarone + Levamlodipine Moderate
- Amobarbital + Levamlodipine Moderate
- Apalutamide + Levamlodipine Moderate
- Aprepitant + Levamlodipine Moderate
- Armodafinil + Levamlodipine Moderate
Frequently asked questions
Can I take Efavirenz with Levamlodipine?
MediHelp rates the interaction as moderate. Efavirenz and Levamlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower levamlodipine concentrations, diminishing antihypertensive effect. Quantitative data are limited, but the interaction is plausible given CYP3A4 involvement.
How serious is the interaction between Efavirenz and Levamlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the levamlodipine dose if needed.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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