Drug interactions
Efavirenz + Omaveloxolone
Severity: Major
Efavirenz and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower omaveloxolone exposure and reduce its therapeutic effect in Friedreich ataxia.
What this interaction means in plain words
Efavirenz and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Omaveloxolone belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4, increasing metabolism of omaveloxolone.
What to do
Avoid combined use if possible and select an antiretroviral that is not an inducer. If it is used together, monitor clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Efavirenz with Omaveloxolone?
MediHelp rates the interaction as major. Efavirenz and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may lower omaveloxolone exposure and reduce its therapeutic effect in Friedreich ataxia.
How serious is the interaction between Efavirenz and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use if possible and select an antiretroviral that is not an inducer. If it is used together, monitor clinical response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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