Drug interactions
Efavirenz + Palbociclib
Severity: Moderate
Efavirenz and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can reduce palbociclib exposure, which may compromise its efficacy in breast cancer treatment.
What this interaction means in plain words
Efavirenz and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Palbociclib belongs to Oncology.
Why it happens
Efavirenz induces CYP3A4, accelerating palbociclib metabolism.
What to do
Avoid combination with moderate or strong CYP3A inducers where possible; consider an alternative antiretroviral and monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Efavirenz with Palbociclib?
MediHelp rates the interaction as moderate. Efavirenz and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can reduce palbociclib exposure, which may compromise its efficacy in breast cancer treatment.
How serious is the interaction between Efavirenz and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination with moderate or strong CYP3A inducers where possible; consider an alternative antiretroviral and monitor tumor response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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