Drug interactions
Efavirenz + Ruxolitinib
Severity: Minor
Efavirenz and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz is a CYP3A4 inducer, so ruxolitinib exposure would more likely fall than rise, although the net effect is modest. Reduced exposure may weaken efficacy, but ruxolitinib has no dose adjustment recommended for inducers in labeling.
What this interaction means in plain words
Efavirenz and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Efavirenz belongs to Anti Virals; Ruxolitinib belongs to Oncology.
Why it happens
Efavirenz may induce CYP3A4-mediated ruxolitinib metabolism, though its mixed effects make the direction uncertain.
What to do
Monitor blood counts, spleen response and symptoms, and adjust ruxolitinib dose per clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Efavirenz with Ruxolitinib?
MediHelp rates the interaction as minor. Efavirenz and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Efavirenz is a CYP3A4 inducer, so ruxolitinib exposure would more likely fall than rise, although the net effect is modest. Reduced exposure may weaken efficacy, but ruxolitinib has no dose adjustment recommended for inducers in labeling.
How serious is the interaction between Efavirenz and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, spleen response and symptoms, and adjust ruxolitinib dose per clinical response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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