Drug interactions
Efavirenz + Stiripentol
Severity: Moderate
Efavirenz and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower stiripentol exposure, potentially reducing seizure control in patients with Dravet syndrome. Seizure breakthrough is the main clinical concern.
What this interaction means in plain words
Efavirenz and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Stiripentol belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4 and other enzymes (e.g. CYP1A2, CYP2C19) that metabolize stiripentol.
What to do
Monitor seizure frequency and, where available, stiripentol concentrations, adjusting the stiripentol dose as needed. Consider a non-inducing antiretroviral regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Efavirenz with Stiripentol?
MediHelp rates the interaction as moderate. Efavirenz and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower stiripentol exposure, potentially reducing seizure control in patients with Dravet syndrome. Seizure breakthrough is the main clinical concern.
How serious is the interaction between Efavirenz and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and, where available, stiripentol concentrations, adjusting the stiripentol dose as needed. Consider a non-inducing antiretroviral regimen if control worsens.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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