Drug interactions
Efavirenz + Tiotropium-olodaterol
Severity: Moderate
Efavirenz and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz can prolong the QT interval, especially at higher exposures, and olodaterol may add a small effect through beta2 stimulation and potassium lowering. The clinical risk is mainly in patients with other proarrhythmic factors.
What this interaction means in plain words
Efavirenz and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Possible additive QT prolongation and beta2-mediated hypokalemia.
What to do
Check an ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Monitor for palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Efavirenz with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Efavirenz and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz can prolong the QT interval, especially at higher exposures, and olodaterol may add a small effect through beta2 stimulation and potassium lowering. The clinical risk is mainly in patients with other proarrhythmic factors.
How serious is the interaction between Efavirenz and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes in patients with cardiac disease or other QT-prolonging drugs. Monitor for palpitations.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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