Drug interactions
Efavirenz + Trazodone
Severity: Moderate
Efavirenz and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and efavirenz may reduce trazodone concentrations by CYP3A4 induction. Combined use may increase arrhythmia risk and also alter antidepressant response.
What this interaction means in plain words
Efavirenz and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and efavirenz induction of CYP3A4 metabolism of trazodone.
What to do
Check ECG and electrolytes in patients with other QT risk factors. Titrate trazodone to clinical response and monitor for sedation or loss of effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Efavirenz with Trazodone?
MediHelp rates the interaction as moderate. Efavirenz and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and efavirenz may reduce trazodone concentrations by CYP3A4 induction. Combined use may increase arrhythmia risk and also alter antidepressant response.
How serious is the interaction between Efavirenz and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes in patients with other QT risk factors. Titrate trazodone to clinical response and monitor for sedation or loss of effect.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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