Drug interactions
Efavirenz + Trimipramine
Severity: Moderate
Efavirenz and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may induce CYP enzymes that metabolize trimipramine, lowering its levels and antidepressant effect. Both drugs can prolong the QT interval, adding arrhythmia risk.
What this interaction means in plain words
Efavirenz and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Trimipramine belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP3A4 and CYP2C19 metabolism of trimipramine, plus additive QT prolongation.
What to do
Monitor clinical response and consider tricyclic levels. Obtain a baseline ECG and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Efavirenz with Trimipramine?
MediHelp rates the interaction as moderate. Efavirenz and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may induce CYP enzymes that metabolize trimipramine, lowering its levels and antidepressant effect. Both drugs can prolong the QT interval, adding arrhythmia risk.
How serious is the interaction between Efavirenz and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider tricyclic levels. Obtain a baseline ECG and correct electrolyte abnormalities.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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