Drug interactions
Efavirenz + Vortioxetine
Severity: Moderate
Efavirenz and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may lower vortioxetine concentrations, potentially reducing antidepressant efficacy.
What this interaction means in plain words
Efavirenz and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efavirenz belongs to Anti Virals; Vortioxetine belongs to Central Nervous System.
Why it happens
Efavirenz induces CYP enzymes, increasing vortioxetine metabolism.
What to do
Monitor depressive symptoms and consider increasing the vortioxetine dose if inducer therapy lasts beyond 14 days, to no more than three times the original dose. Reduce back to the original dose within 14 days of stopping efavirenz.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Efavirenz with Vortioxetine?
MediHelp rates the interaction as moderate. Efavirenz and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efavirenz may lower vortioxetine concentrations, potentially reducing antidepressant efficacy.
How serious is the interaction between Efavirenz and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and consider increasing the vortioxetine dose if inducer therapy lasts beyond 14 days, to no more than three times the original dose. Reduce back to the original dose within 14 days of stopping efavirenz.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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