Drug interactions
Efgartigimod alfa + Ocrelizumab
Severity: Moderate
Efgartigimod alfa and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efgartigimod blocks the neonatal Fc receptor and accelerates IgG catabolism. Ocrelizumab is an IgG1 antibody, so its exposure and effectiveness could be reduced.
What this interaction means in plain words
Efgartigimod alfa and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Efgartigimod alfa belongs to Miscellaneous; Ocrelizumab belongs to Central Nervous System.
Why it happens
Blockade of FcRn by efgartigimod reduces IgG recycling and lowers ocrelizumab concentrations.
What to do
Monitor for reduced ocrelizumab efficacy, such as B-cell repopulation or disease activity. Consider timing infusions away from efgartigimod cycles or choose an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Efgartigimod alfa
- Adalimumab + Efgartigimod alfa Moderate
- Ado-trastuzumab + Efgartigimod alfa Moderate
- Basiliximab + Efgartigimod alfa Moderate
- Bevacizumab + Efgartigimod alfa Moderate
- Brentuximab + Efgartigimod alfa Moderate
- Denosumab + Efgartigimod alfa Moderate
Frequently asked questions
Can I take Efgartigimod alfa with Ocrelizumab?
MediHelp rates the interaction as moderate. Efgartigimod alfa and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Efgartigimod blocks the neonatal Fc receptor and accelerates IgG catabolism. Ocrelizumab is an IgG1 antibody, so its exposure and effectiveness could be reduced.
How serious is the interaction between Efgartigimod alfa and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced ocrelizumab efficacy, such as B-cell repopulation or disease activity. Consider timing infusions away from efgartigimod cycles or choose an alternative.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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