Drug interactions
Elacestrant + Entacapone
Severity: Minor
Elacestrant and Entacapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant is mainly cleared by CYP3A4, and strong or moderate inhibitors raise its exposure. Entacapone is not a recognized clinically meaningful CYP3A4 inhibitor, so this predicted interaction is doubtful.
What this interaction means in plain words
Elacestrant and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elacestrant belongs to Oncology; Entacapone belongs to Central Nervous System.
Why it happens
Predicted weak CYP3A4 inhibition by entacapone; clinical relevance is not established.
What to do
No dose change is generally needed; monitor for elacestrant adverse effects such as nausea and dyslipidemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Entacapone?
MediHelp rates the interaction as minor. Elacestrant and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elacestrant is mainly cleared by CYP3A4, and strong or moderate inhibitors raise its exposure. Entacapone is not a recognized clinically meaningful CYP3A4 inhibitor, so this predicted interaction is doubtful.
How serious is the interaction between Elacestrant and Entacapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for elacestrant adverse effects such as nausea and dyslipidemia.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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