Drug interactions
Elacestrant + Fluconazole
Severity: Major
Elacestrant and Fluconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may substantially raise elacestrant exposure, increasing the risk of its adverse effects such as nausea, dyslipidemia and hepatic effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
What this interaction means in plain words
Elacestrant and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of elacestrant by fluconazole.
What to do
Avoid coadministration and select a non-CYP3A-inhibiting antifungal. If unavoidable, monitor closely for elacestrant toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elacestrant and Fluconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Fluconazole?
MediHelp rates the interaction as major. Elacestrant and Fluconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluconazole may substantially raise elacestrant exposure, increasing the risk of its adverse effects such as nausea, dyslipidemia and hepatic effects. Labeling advises avoiding moderate CYP3A4 inhibitors with elacestrant.
How serious is the interaction between Elacestrant and Fluconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and select a non-CYP3A-inhibiting antifungal. If unavoidable, monitor closely for elacestrant toxicity.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
