Drug interactions
Elacestrant + Fluvoxamine
Severity: Moderate
Elacestrant and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant is metabolized mainly by CYP3A4, and fluvoxamine is a weak to moderate inhibitor, so exposure may increase. This could worsen adverse effects such as nausea and lipid elevations.
What this interaction means in plain words
Elacestrant and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces elacestrant clearance.
What to do
Monitor for elacestrant toxicity or consider an alternative antidepressant. Labeling advises avoiding strong and moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Fluvoxamine?
MediHelp rates the interaction as moderate. Elacestrant and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant is metabolized mainly by CYP3A4, and fluvoxamine is a weak to moderate inhibitor, so exposure may increase. This could worsen adverse effects such as nausea and lipid elevations.
How serious is the interaction between Elacestrant and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for elacestrant toxicity or consider an alternative antidepressant. Labeling advises avoiding strong and moderate CYP3A4 inhibitors.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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