Drug interactions
Elacestrant + Haloperidol
Severity: Moderate
Elacestrant and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP3A4 inhibitor of modest strength, so it may raise elacestrant exposure and increase its adverse effects such as nausea and dyslipidemia. The clinical significance is uncertain.
What this interaction means in plain words
Elacestrant and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of elacestrant by haloperidol, which is predicted to raise elacestrant concentrations.
What to do
Monitor for elacestrant adverse effects such as gastrointestinal intolerance and lipid changes. Consider an alternative antipsychotic if tolerability problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Haloperidol?
MediHelp rates the interaction as moderate. Elacestrant and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Haloperidol is a CYP3A4 inhibitor of modest strength, so it may raise elacestrant exposure and increase its adverse effects such as nausea and dyslipidemia. The clinical significance is uncertain.
How serious is the interaction between Elacestrant and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for elacestrant adverse effects such as gastrointestinal intolerance and lipid changes. Consider an alternative antipsychotic if tolerability problems arise.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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