Drug interactions
Elacestrant + Itraconazole
Severity: Major
Elacestrant and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases elacestrant exposure because elacestrant is mainly cleared by CYP3A4. This may increase adverse effects such as nausea, dyslipidemia and hepatic enzyme elevations.
What this interaction means in plain words
Elacestrant and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition reduces elacestrant clearance.
What to do
Avoid concomitant use and choose an antifungal without strong CYP3A4 inhibition. If it cannot be avoided, monitor for elacestrant toxicity including liver tests and lipids.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Itraconazole?
MediHelp rates the interaction as major. Elacestrant and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases elacestrant exposure because elacestrant is mainly cleared by CYP3A4. This may increase adverse effects such as nausea, dyslipidemia and hepatic enzyme elevations.
How serious is the interaction between Elacestrant and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an antifungal without strong CYP3A4 inhibition. If it cannot be avoided, monitor for elacestrant toxicity including liver tests and lipids.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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