Drug interactions
Elacestrant + Ribociclib
Severity: Major
Elacestrant and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase elacestrant exposure, raising the risk of adverse effects such as nausea and dyslipidemia. Elacestrant is a CYP3A4 substrate, and moderate inhibitors raise its levels.
What this interaction means in plain words
Elacestrant and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing elacestrant metabolism.
What to do
Avoid concomitant use where possible and consider an alternative regimen. If required, monitor for increased adverse effects of elacestrant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Ribociclib?
MediHelp rates the interaction as major. Elacestrant and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib may increase elacestrant exposure, raising the risk of adverse effects such as nausea and dyslipidemia. Elacestrant is a CYP3A4 substrate, and moderate inhibitors raise its levels.
How serious is the interaction between Elacestrant and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and consider an alternative regimen. If required, monitor for increased adverse effects of elacestrant.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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