Drug interactions
Elacestrant + Sirolimus
Severity: Moderate
Elacestrant and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant may inhibit intestinal P-glycoprotein and could increase sirolimus absorption and exposure. The clinical effect is predicted rather than well documented, but sirolimus has a narrow therapeutic range.
What this interaction means in plain words
Elacestrant and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Elacestrant inhibits P-glycoprotein efflux, potentially increasing sirolimus bioavailability.
What to do
Monitor sirolimus trough levels when elacestrant is started or stopped and reduce the sirolimus dose if concentrations are elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Sirolimus?
MediHelp rates the interaction as moderate. Elacestrant and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant may inhibit intestinal P-glycoprotein and could increase sirolimus absorption and exposure. The clinical effect is predicted rather than well documented, but sirolimus has a narrow therapeutic range.
How serious is the interaction between Elacestrant and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels when elacestrant is started or stopped and reduce the sirolimus dose if concentrations are elevated.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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