Drug interactions
Elacestrant + Tacrolimus
Severity: Moderate
Elacestrant and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elacestrant inhibits P-glycoprotein and may increase tacrolimus exposure. Because tacrolimus has a narrow therapeutic index, small increases may matter.
What this interaction means in plain words
Elacestrant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elacestrant belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases tacrolimus absorption.
What to do
Monitor tacrolimus trough levels and renal function when elacestrant is started or stopped, and reduce the tacrolimus dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Tacrolimus?
MediHelp rates the interaction as moderate. Elacestrant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elacestrant inhibits P-glycoprotein and may increase tacrolimus exposure. Because tacrolimus has a narrow therapeutic index, small increases may matter.
How serious is the interaction between Elacestrant and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels and renal function when elacestrant is started or stopped, and reduce the tacrolimus dose if levels rise.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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