Drug interactions
Elacestrant + Voriconazole
Severity: Major
Elacestrant and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole, a strong CYP3A4 inhibitor, increases elacestrant exposure. Higher levels may worsen nausea, musculoskeletal pain and dyslipidemia.
What this interaction means in plain words
Elacestrant and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Elacestrant belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated elacestrant metabolism.
What to do
Avoid concomitant use of elacestrant with strong CYP3A4 inhibitors and select an alternative antifungal. If unavoidable, monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Elacestrant with Voriconazole?
MediHelp rates the interaction as major. Elacestrant and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole, a strong CYP3A4 inhibitor, increases elacestrant exposure. Higher levels may worsen nausea, musculoskeletal pain and dyslipidemia.
How serious is the interaction between Elacestrant and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of elacestrant with strong CYP3A4 inhibitors and select an alternative antifungal. If unavoidable, monitor for adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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