Drug interactions
Elagolix + Empagliflozin-linagliptin
Severity: Minor
Elagolix and Empagliflozin-linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A inducer and also affects P-glycoprotein, so it may alter linagliptin exposure in either direction. The clinical effect on glycemic control is expected to be small and is not well characterized.
What this interaction means in plain words
Elagolix and Empagliflozin-linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Empagliflozin-linagliptin belongs to Endocrine.
Why it happens
Elagolix induces CYP3A4 and modulates P-glycoprotein, which may change linagliptin clearance and absorption.
What to do
No empiric dose change is needed; check blood glucose if control worsens after elagolix is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin-linagliptin
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Empagliflozin-linagliptin?
MediHelp rates the interaction as minor. Elagolix and Empagliflozin-linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A inducer and also affects P-glycoprotein, so it may alter linagliptin exposure in either direction. The clinical effect on glycemic control is expected to be small and is not well characterized.
How serious is the interaction between Elagolix and Empagliflozin-linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; check blood glucose if control worsens after elagolix is started.
What other medicines interact with Empagliflozin-linagliptin?
MediHelp also lists interactions of Empagliflozin-linagliptin with, for example, Fosphenytoin, Rifampin, Rifapentine. The full list is on the Empagliflozin-linagliptin page.
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