Drug interactions
Elagolix + Ethinyl estradiol-norgestimate
Severity: Moderate
Elagolix and Ethinyl estradiol-norgestimate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may reduce hormone exposure from combined contraceptives. Elagolix itself acts on the hormonal axis and the two agents have opposing hormonal intent, so the combination is generally not used together for contraception.
What this interaction means in plain words
Elagolix and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Elagolix induces CYP3A4, increasing metabolism of ethinyl estradiol and norgestimate metabolites.
What to do
Use effective non-hormonal contraception during elagolix therapy and review whether concurrent estrogen-progestin use is appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as moderate. Elagolix and Ethinyl estradiol-norgestimate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a weak to moderate CYP3A4 inducer and may reduce hormone exposure from combined contraceptives. Elagolix itself acts on the hormonal axis and the two agents have opposing hormonal intent, so the combination is generally not used together for contraception.
How serious is the interaction between Elagolix and Ethinyl estradiol-norgestimate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use effective non-hormonal contraception during elagolix therapy and review whether concurrent estrogen-progestin use is appropriate.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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