Drug interactions
Elagolix + Exemestane
Severity: Minor
Elagolix and Exemestane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may modestly lower exemestane levels. The combination is unusual because both affect estrogen pathways, and any loss of exemestane effect would be of limited predictability.
What this interaction means in plain words
Elagolix and Exemestane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Exemestane belongs to Oncology.
Why it happens
Elagolix induces CYP3A4, modestly increasing exemestane clearance.
What to do
Review whether concurrent use is needed at all, as the two have opposing roles in hormonal therapy. If used together, monitor clinical response to exemestane.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exemestane
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Exemestane?
MediHelp rates the interaction as minor. Elagolix and Exemestane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and may modestly lower exemestane levels. The combination is unusual because both affect estrogen pathways, and any loss of exemestane effect would be of limited predictability.
How serious is the interaction between Elagolix and Exemestane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether concurrent use is needed at all, as the two have opposing roles in hormonal therapy. If used together, monitor clinical response to exemestane.
What other medicines interact with Exemestane?
MediHelp also lists interactions of Exemestane with, for example, Bazedoxifene-conjugated estrogens, Desogestrel-ethinyl estradiol, Estradiol. The full list is on the Exemestane page.
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