Drug interactions
Elagolix + Fentanyl
Severity: Minor
Elagolix and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may modestly lower fentanyl concentrations. This could reduce analgesic effect, and levels may rise again once elagolix is stopped.
What this interaction means in plain words
Elagolix and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Fentanyl belongs to Musculoskeletal.
Why it happens
Induction of CYP3A4 by elagolix increases fentanyl metabolism.
What to do
Monitor analgesic response and titrate fentanyl if pain control is inadequate. Watch for increased opioid effects after elagolix discontinuation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Fentanyl?
MediHelp rates the interaction as minor. Elagolix and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may modestly lower fentanyl concentrations. This could reduce analgesic effect, and levels may rise again once elagolix is stopped.
How serious is the interaction between Elagolix and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and titrate fentanyl if pain control is inadequate. Watch for increased opioid effects after elagolix discontinuation.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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