Drug interactions
Elagolix + Isoniazid
Severity: Moderate
Elagolix and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a CYP3A substrate, and strong CYP3A inhibitors raise its exposure, increasing the risk of bone mineral density loss and other dose-related effects. Isoniazid is only a weak-to-moderate CYP3A inhibitor, so the increase is probably modest. The risk is greatest with longer durations of therapy.
What this interaction means in plain words
Elagolix and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, reducing the first-pass and systemic metabolism of elagolix.
What to do
Limit the duration of concurrent use, and follow the elagolix labeling for limits on dose and duration with CYP3A inhibitors. Monitor for hypoestrogenic adverse effects such as bone loss and hot flushes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Isoniazid?
MediHelp rates the interaction as moderate. Elagolix and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a CYP3A substrate, and strong CYP3A inhibitors raise its exposure, increasing the risk of bone mineral density loss and other dose-related effects. Isoniazid is only a weak-to-moderate CYP3A inhibitor, so the increase is probably modest. The risk is greatest with longer durations of therapy.
How serious is the interaction between Elagolix and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of concurrent use, and follow the elagolix labeling for limits on dose and duration with CYP3A inhibitors. Monitor for hypoestrogenic adverse effects such as bone loss and hot flushes.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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