Drug interactions
Elagolix + Ketamine
Severity: Minor
Elagolix and Ketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak-to-moderate CYP3A4 inducer and may lower ketamine exposure, since CYP3A4 contributes to ketamine N-demethylation. The clinical effect is usually modest and may appear as a reduced anesthetic or analgesic response.
What this interaction means in plain words
Elagolix and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Ketamine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by elagolix increases ketamine metabolism.
What to do
Titrate ketamine to clinical effect and be ready to give slightly higher doses if response is inadequate. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ketamine?
MediHelp rates the interaction as minor. Elagolix and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak-to-moderate CYP3A4 inducer and may lower ketamine exposure, since CYP3A4 contributes to ketamine N-demethylation. The clinical effect is usually modest and may appear as a reduced anesthetic or analgesic response.
How serious is the interaction between Elagolix and Ketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical effect and be ready to give slightly higher doses if response is inadequate. No routine dose change is needed.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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