Drug interactions
Elagolix + Lansoprazole
Severity: Minor
Elagolix and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix weakly inhibits CYP2C19 and induces CYP3A4, so lansoprazole exposure could change in either direction. Clinically important effects are not expected for most patients.
What this interaction means in plain words
Elagolix and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Weak CYP2C19 inhibition and weak-to-moderate CYP3A4 induction by elagolix alter lansoprazole metabolism.
What to do
No routine adjustment is required; assess PPI response and tolerability and adjust the lansoprazole dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Lansoprazole?
MediHelp rates the interaction as minor. Elagolix and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix weakly inhibits CYP2C19 and induces CYP3A4, so lansoprazole exposure could change in either direction. Clinically important effects are not expected for most patients.
How serious is the interaction between Elagolix and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; assess PPI response and tolerability and adjust the lansoprazole dose if needed.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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