Drug interactions
Elagolix + Phenytoin
Severity: Moderate
Elagolix and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, as a strong CYP3A4 inducer, may substantially reduce elagolix exposure and efficacy. Elagolix weakly inhibits CYP2C19, which may modestly affect phenytoin.
What this interaction means in plain words
Elagolix and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4 increasing elagolix clearance; elagolix weakly inhibits CYP2C19.
What to do
Avoid long-term combination where possible, as strong inducers are not recommended with elagolix. Monitor phenytoin levels if coadministered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Phenytoin?
MediHelp rates the interaction as moderate. Elagolix and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin, as a strong CYP3A4 inducer, may substantially reduce elagolix exposure and efficacy. Elagolix weakly inhibits CYP2C19, which may modestly affect phenytoin.
How serious is the interaction between Elagolix and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination where possible, as strong inducers are not recommended with elagolix. Monitor phenytoin levels if coadministered.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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