Drug interactions
Elagolix + Rabeprazole
Severity: Minor
Elagolix and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak CYP2C19 inhibitor and a weak-to-moderate CYP3A inducer, so it could change rabeprazole exposure in either direction. Because rabeprazole is cleared largely non-enzymatically, any effect is expected to be small.
What this interaction means in plain words
Elagolix and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Elagolix weakly inhibits CYP2C19 and induces CYP3A4, both minor routes for rabeprazole.
What to do
No dose adjustment is routinely needed; monitor for changes in reflux control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Rabeprazole?
MediHelp rates the interaction as minor. Elagolix and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak CYP2C19 inhibitor and a weak-to-moderate CYP3A inducer, so it could change rabeprazole exposure in either direction. Because rabeprazole is cleared largely non-enzymatically, any effect is expected to be small.
How serious is the interaction between Elagolix and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed; monitor for changes in reflux control.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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