Drug interactions
Elagolix + Telmisartan
Severity: Moderate
Elagolix and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a substrate of OATP1B1, and inhibitors of this transporter markedly raise its plasma concentrations. Telmisartan is not generally regarded as a strong OATP1B1 inhibitor, so the contraindication is probably an overextension of the class warning and the clinical significance is uncertain.
What this interaction means in plain words
Elagolix and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of elagolix, which is not well established for telmisartan.
What to do
Monitor for elagolix adverse effects such as hot flushes, headache and liver enzyme elevation. Reassess if symptoms or liver test abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Telmisartan?
MediHelp rates the interaction as moderate. Elagolix and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a substrate of OATP1B1, and inhibitors of this transporter markedly raise its plasma concentrations. Telmisartan is not generally regarded as a strong OATP1B1 inhibitor, so the contraindication is probably an overextension of the class warning and the clinical significance is uncertain.
How serious is the interaction between Elagolix and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for elagolix adverse effects such as hot flushes, headache and liver enzyme elevation. Reassess if symptoms or liver test abnormalities develop.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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