Drug interactions
Elagolix + Theophylline
Severity: Minor
Elagolix and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak to moderate CYP3A4 inducer and may modestly lower exposure to CYP3A substrates. Theophylline is mainly metabolized by CYP1A2, so any reduction is likely small, but loss of efficacy is possible.
What this interaction means in plain words
Elagolix and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Theophylline belongs to Respiratory.
Why it happens
Weak to moderate CYP3A4 induction by elagolix may increase minor theophylline metabolic pathways.
What to do
Monitor clinical response and consider checking a theophylline level if control worsens after elagolix is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Theophylline?
MediHelp rates the interaction as minor. Elagolix and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak to moderate CYP3A4 inducer and may modestly lower exposure to CYP3A substrates. Theophylline is mainly metabolized by CYP1A2, so any reduction is likely small, but loss of efficacy is possible.
How serious is the interaction between Elagolix and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider checking a theophylline level if control worsens after elagolix is started.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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