Drug interactions
Elagolix + Ulipristal
Severity: Moderate
Elagolix and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a CYP3A4 inducer and may lower ulipristal exposure, possibly reducing emergency contraception efficacy. Elagolix also affects hormonal pathways, and ulipristal's progesterone receptor activity may be altered.
What this interaction means in plain words
Elagolix and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by elagolix reducing ulipristal concentrations.
What to do
Advise a non-hormonal emergency option such as a copper IUD if feasible. Recommend reliable non-hormonal backup contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ulipristal?
MediHelp rates the interaction as moderate. Elagolix and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix is a CYP3A4 inducer and may lower ulipristal exposure, possibly reducing emergency contraception efficacy. Elagolix also affects hormonal pathways, and ulipristal's progesterone receptor activity may be altered.
How serious is the interaction between Elagolix and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise a non-hormonal emergency option such as a copper IUD if feasible. Recommend reliable non-hormonal backup contraception.
What other medicines interact with Elagolix?
MediHelp also lists interactions of Elagolix with, for example, Cyclosporin, Gemfibrozil, Desogestrel-ethinyl estradiol. The full list is on the Elagolix page.
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